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KMID : 0043319950180060410
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Archives of Pharmacal Research
1995 Volume.18 No. 6 p.410 ~ p.414
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Adaptive Response Induced by Low Dose Ionizing Raditation in Human Cervical Carcinoma Cells
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Kim Jeong-Hee
Lee Kyung-Jong
Cho Chul-Koo
Yoo Seong-Yul
Kim Tae-Hwan
Ji Young-Hoon
Kim Sung-Ho
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Abstract
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Adaptive response induced by low dese .gamma.-ray irradiation in human cervical carcinoma cells was examined. Cells were exposured to low dose of .gamma.-ray irradiation in human cervical carcinoma cells was examined. Cells were exposured to low dose of .gamma.-ray (1-cGy) followed by high doses of r-ray irradiation (0,1,2,3,5,7 and 9Gy for chlnogenic assay or 1.5Gy for micronucleus assay) with various time intervals. Survival fractions of cells in both low dose-irradiated and unirrated groups were analyzed by clonogenic assay. Surviva fractions of low dose-irradiated in cell survival was maximum when low and high dose irradiation time interval was 4 hr. Frequencies of micronuclei which is an indicative of chromosome aberration were also enutained from survival fractions analyzed by clonogenic assay, maximum when low and high dose irradiation time interval was 4hr. Frequencies of micronuclei which is an indicative of chromosome aberration were also enumerated in both low dose-irradiated and unirradiated groups. In consiststent with the result obtained from survival fractions analyzed by clonogenic assay, maximum reduction in frquencies of micronuclei was observed when low dose radiation was given 4 hr prior to high response to subsequent high dose .gamma.-ray irradiation in human cervical carcinomal cells. Our data suggest that one of the possible mechanisms of adaptive response induced by low dose rediation is the increase in repair of DNA double strand breaks in low dose radiation-adapted cells.
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KEYWORD
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Radiation-induced adaptive, response, Survival fraction, Micronuleus assay, Gamma-ray, Human cervical carcinoma cells
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